(1) Cov khoom siv raw
Cov khoom siv raw ntawm HPMC hollow capsule feem ntau yog los ntawm cov nroj tsuag ntshiab fiber ntau ( ntoo thuv), uas yog ib puag ncig tus phooj ywg, nyab xeeb thiab txhim khu kev qha.
Gelatin hollow capsule feem ntau yog muab los ntawm collagen hauv cov tawv nqaij thiab pob txha.Nyob rau hauv cov txheej txheem extraction, ib tug loj npaum li cas ntawm cov tshuaj Cheebtsam yog ntxiv, uas yog ib qho yooj yim mus qhia pathogenes ntawm cov nyuj vwm kab mob thiab ko taw thiab qhov ncauj kab mob, thiab lwm yam.,.Nyob rau hauv xyoo tas los no, qhov xwm txheej "Poison Capsule" tau nthuav tawm ntau yam teeb meem ntawm cov tshuaj gelatin ib txwm siv, xws li "cov kua nplaum tawv xiav" nthuav tawm los ntawm cov xov xwm, ua rau cov chromium hauv cov tshuaj ntsiav tau dhau tus qauv.
(2) Applicability & Chemical Stability
HPMC yog cellulose derivative nrog muaj zog inertness, dav siv tau, ruaj khov tshuaj, tsis muaj kev sib txuas cov tshuaj tiv thaiv nrog aldehyde-muaj tshuaj, thiab tsis muaj kev cuam tshuam qeeb.
Lysine tseem nyob hauv gelatin, Thaum siv gelatin hauv tshuaj ntsiav, yuav muaj qhov tshwm sim qeeb qeeb.Cov ntsiab lus ntawm cov tshuaj txo qis heev yuav muaj cov tshuaj tiv thaiv Maillard nrog gelatin (Browning Reaction).Yog tias cov tshuaj muaj aldehyde, txo cov piam thaj hauv cov tshuaj, lossis vitamin C, nws tsis tsim nyog siv rau hauv gelatin hollow capsule.
(3) Cov ntsiab lus dej
Cov dej ntsiab lus ntawm gelatin hollow capsule yog li 12.5% mus rau 17.5%.Lub gelatin capsule nrog dej siab nyiam nqus cov dej noo ntawm cov ntsiab lus ntawm cov tshuaj los yog nqus dej los ntawm nws cov ntsiab lus sau, ua rau cov tshuaj ntsiav mos los yog nkig, cuam tshuam rau cov tshuaj puv nws tus kheej.
Cov dej ntsiab lus ntawm HPMC hollow capsule yog li ntawm 3% mus rau 9%, uas yuav tsis hnov mob nrog cov ntsiab lus sau, thiab tuaj yeem tuav lub cev zoo xws li tawv thaum sau cov tshuaj sib txawv, tshwj xeeb tshaj yog tsim rau hygroscopicity thiab sau cov dej noo. tshuaj rhiab heev.
(4) Preservative residue
Lub ntsiab tseem ceeb ntawm gelatin hollow capsule yog cov protein, uas yooj yim rau yug cov kab mob thiab kab mob.Cov tshuaj tua kab mob thiab cov kab mob bacteriostatic, tuaj yeem tso rau hauv cov tshuaj ntsiav kom tiv thaiv kev loj hlob ntawm microbial thaum lub sijhawm tsim khoom.Yog hais tias tus nqi ntau tshaj ib qho, cov ntsiab lus arsenic nws thiaj li yuav dhau.Nyob rau tib lub sijhawm, gelatin hollow capsules yuav tsum tau ua kom tsis muaj menyuam los ntawm ethylene oxide tom qab kev tsim khoom tiav, thiab yuav muaj chlorohydrin tom qab ethylene oxide sterilization.Thaum Chlorohydrin residues raug txwv tsis pub siv.
HPMC hollow capsules tsis tas yuav ntxiv cov tshuaj tua kab mob hauv cov txheej txheem tsim khoom, tsis tas yuav ua kom tsis muaj menyuam, tuaj yeem ua tau raws li lub teb chaws tus qauv, thiab cov tshuaj ntsuab ntsuab tsis muaj cov khoom seem thiab cov khoom noj.
(5) Kev ruaj khov
HPMC hollow capsules muaj xoob cia tej yam kev mob, ntawm ib tug kub ntawm 10 mus rau 30 ° C, thiab cov av noo ntawm 35% thiab 65%, uas tsis soften los yog harden thiab nkig.HPMC hollow capsule muaj friability ntawm ≤ 2% ntawm cov av noo ntawm 35% thiab cov tshuaj ntsiav hloov ntawm ≤ 1% ntawm qhov kub ntawm 80 ° C;Kev khaws cia thiab thauj hauv txhua thaj chaw huab cua tsis muaj teeb meem.
Gelatin capsules yog nquag mus adhesion nyob rau hauv high humidity tej yam kev mob;hardening los yog friability nyob rau hauv qis-humidity tej yam kev mob, thiab muaj zog dependence nyob rau hauv lub kub thiab humidity ntawm cia ib puag ncig.
(6) Tus phooj ywg environmentally
Lub extraction ntawm HPMC hollow capsule raw cov ntaub ntawv yog nqa tawm los ntawm lub cev extraction.Nws yog muab rho tawm los ntawm ntoo thuv thiab tsis tsim rotten stench.Nws kuj zoo heev txo cov dej siv thiab txo cov pa phem ib puag ncig.Tsis muaj cov tshuaj phem ntxiv thaum lub sijhawm ua haujlwm thiab tsis muaj kev ua qias tuaj ib puag ncig.
Gelatin hollow capsules yog ua los ntawm cov tsiaj tawv nqaij thiab pob txha raws li cov ntaub ntawv raw, uas yog chemically reacted thiab fermented.Cov txheej txheem ntxiv cov khoom siv tshuaj lom neeg ntau, ua rau muaj ntxhiab tsw loj thaum lub sijhawm tsim khoom, thiab siv cov dej ntau ntau.Ua kom muaj kuab paug loj;Tsis tas li ntawd gelatin pov tseg rov ua dua yog tsawg, thiab ntau qhov chaw muaj kuab paug raug tsim tawm thaum pov tseg nws cov khoom pov tseg.
(7) Kev sib cuag nrog huab cua sab nraud
Cov khoom siv raw ntawm HPMC hollow capsules txiav txim siab tias nws tuaj yeem cais cov ntsiab lus los ntawm lub ntiaj teb sab nraud thiab zam kev cuam tshuam nrog huab cua, thiab nws lub neej txee feem ntau yog 24 lub hlis.
Lub gelatin capsule muaj lub sijhawm ua haujlwm zoo li ntawm 18 lub hlis, thaum tseem muaj sijhawm cia ua ntej siv ua rau cov tshuaj ntsiav muaj lub sijhawm luv luv, uas cuam tshuam ncaj qha rau lub txee lub neej ntawm cov tshuaj.
(8) Inhibiting kab mob loj hlob
Lub ntsiab raw khoom ntawm HPMC hollow capsules yog cov nroj tsuag fiber, uas tsis tsuas yog tsis proliferate kab mob, tab sis kuj inhibits kab mob loj hlob.Cov kev sim tau pom tias HPMC hollow capsules tuaj yeem khaws cia rau hauv ib puag ncig ib puag ncig ntev, thiab tus naj npawb ntawm cov kab mob tuaj yeem khaws cia raws li tus qauv.
Cov khoom siv tseem ceeb ntawm gelatin hollow capsule yog collagen, thiab collagen yog cov kab mob kab mob nruab nrab, uas pab cov kab mob sib kis.Yog tias qhov kev kho mob tsis raug, cov kab mob yuav dhau los ntawm tus qauv thiab yuav ntau ntxiv.
Xaus.
Post lub sij hawm: Lub Xya hli ntuj-28-2022