Xyoo 1990, Pfizer tau ua tus thawj coj hauv kev tsim thiab sau npe lub ntiaj teb thawj cov khoom tsis yog gelatin capsule plhaub, cov khoom siv tseem ceeb ntawm cov cellulose ester "hydroxypropyl methyl cellulose" los ntawm cov nroj tsuag.Vim tias hom tshuaj ntsiav tshiab no tsis muaj cov khoom xyaw tsiaj, nws tau txais kev qhuas los ntawm kev lag luam raws li "cog capsule".Tam sim no, txawm hais tias qhov muag ntim ntawm cov tshuaj ntsiav tshuaj nyob rau hauv lub thoob ntiaj teb capsule kev ua lag luam tsis siab, nws txoj kev loj hlob lub zog muaj zog heev, nrog rau kev lag luam loj hlob qhov chaw.
　　
"Nrog rau txoj kev loj hlob ntawm kev kho mob science thiab technology thiab lwm yam sciences, qhov tseem ceeb ntawm cov tshuaj excipients nyob rau hauv zus tau tej cov tshuaj npaj tau maj mam lees paub, thiab cov xwm txheej ntawm lub tsev muag tshuaj yog nce."Ouyang Jingfeng, tus kws tshawb fawb koom nrog hauv Suav Academy ntawm Suav Kev Tshawb Fawb Txog Kev Kho Mob, tau taw qhia tias cov tshuaj excipients tsis tsuas yog txiav txim siab txog qhov zoo ntawm cov ntawv siv tshuaj tshiab thiab kev npaj tshiab ntawm cov tshuaj mus rau qhov tseem ceeb, tab sis kuj pab kev npaj tsim, stabilize, solubilize. , nce solubilize, ncua kev tso tawm, ncua kev tso tawm, tswj kev tso tawm, kev taw qhia, lub sijhawm, qhov chaw, ua haujlwm sai, ua haujlwm tau zoo thiab ua haujlwm ntev, thiab hauv kev txiav txim siab, kev txhim kho ntawm cov khoom siv tshiab zoo tuaj yeem ua rau kev loj hlob ntawm cov chav kawm loj. ntawm ntau npaum li cas cov ntaub ntawv, txhim kho qhov zoo ntawm ib tug loj tus naj npawb ntawm cov tshuaj tshiab thiab kev npaj, thiab nws qhov tseem ceeb nyob deb tshaj txoj kev loj hlob ntawm ib tug tshiab tshuaj.Nyob rau hauv cov ntaub ntawv tshuaj noj xws li tshuaj pleev, ntsiav tshuaj, txhaj tshuaj, thiab tshuaj ntsiav, tshuaj ntsiav tau dhau los ua cov ntaub ntawv tseem ceeb ntawm kev npaj ntawm qhov ncauj vim lawv cov bioavailability siab, txhim kho kev ruaj ntseg ntawm cov tshuaj, thiab teem sij hawm thiab tso tshuaj.

Tam sim no, cov khoom siv tseem ceeb rau kev tsim cov tshuaj ntsiav yog gelatin, gelatin yog tsim los ntawm hydrolysis ntawm cov pob txha tsiaj thiab tawv nqaij, thiab yog ib qho macromolecule lom nrog ib tug ternary kauv qauv, nrog zoo biocompatibility thiab lub cev thiab tshuaj.Txawm li cas los xij, gelatin capsules kuj muaj qee qhov kev txwv hauv daim ntawv thov, thiab kev txhim kho cov ntaub ntawv tshiab rau cov tshuaj ntsiav ntawm lub hauv paus tsis yog tsiaj txhu tau dhau los ua qhov chaw kub hauv kev tshawb fawb tsis ntev los no ntawm cov tshuaj excipients.Wu Zhenghong, tus xibfwb ntawm Tuam Tshoj Pharmaceutical University, tau hais tias vim yog "tus kab mob nyuj vwm" hauv cov tebchaws nyob sab Europe xws li Britain, Fabkis thiab Netherlands hauv xyoo 1990 (xws li Nyiv hauv Asia, uas kuj pom cov nyuj vwm nrog cov nyuj vwm) , cov neeg ntawm Western lub teb chaws muaj kev tsis ntseeg siab ntawm cov nqaij nyug thiab nyuj cov khoom lag luam (gelatin kuj yog ib qho ntawm lawv).Tsis tas li ntawd, cov neeg ntseeg thiab cov neeg tsis noj nqaij kuj tiv taus cov gelatin capsules uas ua los ntawm cov tsiaj nyeg.Raws li qhov no, qee lub tuam txhab tshuaj ntsiav txawv teb chaws tau pib kawm cov ntaub ntawv tshiab rau cov tshuaj ntsiav uas tsis yog gelatin thiab lwm yam tsiaj, thiab kev tswj hwm ntawm cov tshuaj ntsiav tshuaj gelatin tau pib hloov zuj zus.

Nrhiav cov ntaub ntawv tshiab los npaj cov tshuaj ntsiav uas tsis yog gelatin yog tam sim no txoj kev loj hlob ntawm cov tshuaj excipients.Ouyang Jingfeng tau taw qhia tias cov khoom siv raw ntawm cov tshuaj ntsuab tam sim no yog hydroxypropyl methylcellulose, hloov cov hmoov txhuv nplej siab thiab qee cov khoom noj khoom haus hydrophilic polymer, xws li gelatin, carrageenan, xanthan gum thiab lwm yam.Hydroxypropyl methyl cellulose capsules muaj zoo li solubility, disintegration thiab bioavailability rau gelatin capsules, thaum muaj qee qhov zoo uas gelatin capsules tsis muaj, tab sis daim ntawv thov tam sim no tseem tsis tau nthuav dav, feem ntau yog vim tus nqi siab ntawm cov khoom, piv nrog gelatin, hydroxypropyl methyl cellulose capsule raw khoom nqi yog siab dua, ntxiv rau cov gel qeeb qeeb, ua rau lub voj voog ntev ntau lawm.

Hauv kev lag luam thoob ntiaj teb kev lag luam, cov tshuaj ntsiav tshuaj yog ib qho ntawm cov khoom lag luam loj tshaj plaws.Wu Zhenghong tau hais tias piv nrog gelatin capsules, cov tshuaj ntsiav tshuaj muaj cov txiaj ntsig zoo hauv qab no: Ua ntej, tsis muaj cov tshuaj tiv thaiv crosslinking.Nroj tsuag capsules muaj zog inertness thiab tsis yooj yim rau crosslink nrog aldehyde pawg lossis lwm cov tebchaw.Qhov thib ob yog tsim rau cov tshuaj uas muaj dej-rhiab heev.Cov ntsiab lus noo noo ntawm cov nroj tsuag capsules feem ntau tswj ntawm 5% thiab 8%, thiab nws tsis yooj yim rau chemically hnov ​​​​mob nrog cov ntsiab lus, thiab cov ntsiab lus dej qis ua kom muaj kev ruaj ntseg ntawm cov ntsiab lus hygroscopic uas cuam tshuam rau cov dej noo.Qhov thib peb yog zoo compatibility nrog lub ntsiab kws excipients.Zaub capsules muaj kev sib raug zoo nrog lactose, dextrin, hmoov txhuv nplej siab, microcrystalline cellulose, magnesium stearate thiab lwm yam tseem ceeb siv tshuaj excipients.Qhov thib plaub yog kom muaj ib qho chaw so ntau dua.Nroj tsuag capsules muaj qhov xav tau xoob heev rau qhov chaw ua haujlwm ntawm cov khoom ntim, txawm tias nws yog qhov yuav tsum tau ua rau qhov chaw ua haujlwm lossis tus nqi dhau ntawm lub tshuab, uas tuaj yeem txo tus nqi siv.
　
　
"Nyob hauv lub ntiaj teb no, cov nroj tsuag capsules tseem nyob rau hauv lawv cov me nyuam mos, tsuas yog ob peb lub lag luam tuaj yeem tsim cov tshuaj ntsuab tshuaj ntsuab, thiab nws yog qhov tsim nyog los ntxiv dag zog rau kev tshawb fawb hauv cov txheej txheem ntau lawm thiab lwm yam, thaum tseem ua rau kev lag luam nce qib."Ouyang Jingfeng tau taw qhia tias tam sim no, cov khoom tsim tawm ntawm gelatin capsules hauv Suav teb tau mus txog thawj qhov chaw hauv ntiaj teb, thaum lub khw muag khoom ntawm cov khoom siv tshuaj ntsuab tseem tsawg.Tsis tas li ntawd, vim tias cov txheej txheem ntawm kev tsim cov tshuaj ntsiav tsis tau hloov pauv rau ntau tshaj li ib puas xyoo, thiab kev txhim kho txuas ntxiv ntawm cov cuab yeej tsim los ntawm cov txheej txheem tsim cov gelatin, yuav ua li cas siv cov txheej txheem thiab cov khoom siv los npaj cov gelatin capsules los npaj cov nroj tsuag. Cov tshuaj ntsiav tau dhau los ua qhov tseem ceeb ntawm kev tshawb fawb, uas suav nrog kev kawm tshwj xeeb ntawm cov txheej txheem xws li viscosity, rheological zog thiab viscoelasticity ntawm cov ntaub ntawv.
　　

Txawm hais tias nws tsis muaj peev xwm cog cov tshuaj ntsiav los hloov qhov kev tswj hwm ntawm cov tshuaj gelatin hollow capsules, cov tshuaj ntsiav tshuaj muaj qhov zoo sib tw hauv Suav teb cov tshuaj suav tshuaj, tshuaj lom neeg thiab khoom noj khoom haus.Zhang Youde, tus kws tshaj lij ntawm Lub Tsev Kawm Ntawv ntawm Cov Khoom Siv Science thiab Engineering ntawm Beijing Institute of Technology, ntseeg hais tias nrog tib neeg kev nkag siab tob txog cov tshuaj ntsiav thiab kev hloov pauv ntawm pej xeem cov tswv yim tshuaj, kev ua lag luam xav tau rau cov tshuaj ntsiav tshuaj yuav loj hlob sai.